Seabit Oral Powder

SEABIT Veterinary Medicated Premix/Oral Powder is a white cream colored, odorless, fine-particle powder formulation containing 2 mg Emamectin benzoate in 1 gram.

Pharmacological Properties

Emamectin benzoate, which is SEABIT Oral Powder/Veterinary Medicated Premix , is a semi-synthetic derivative of avermectin, a broad-spectrum macrocyclic lactone obtained from the fermentation product of Streptomyces avermectinius’. It is characterized by having a 16-membered lactone ring and a dioleandrosyl group attached to it. The benzoate salt provides stability to the molecule. Although the mechanism of action of Emamectin benzoate is not known precisely, studies show that avermectins bind competitively to glutamate-mediated chloride channels in the nerve fibers of invertebrates. The distribution of glutamate-chloride channels in invertebrates is localized in specific muscles such as the pharyngeal pump. By opening these channels, it increases the permeability of the cell membrane to chloride ions, resulting in hyperpolarization in the cell, and the parasite dies as paralyzed. Emamectin benzoate is absorbed slowly but distributed widely to the tissues. Its excretion from the body is also quite slow.

Indications

Unless otherwise recommended by the veterinarian;
SEABITOral Powder/Veterinary Medicated Premix, is used for the treatment against the parasite seen in cultured Salmon fish  (Salmo salar) and the parasites (Lepeophtheirus sp. and Caligus sp.) in Rainbow trout (Oncorhynchus mykiss).

Usage and Dosage

“Unless otherwise recommended by the veterinarian.”
SEABITOral Powder/Veterinary Medicated Premix is used orally by mixing it into the feed. The pharmacological dose of Emamectin benzoate is 50 µg/kg body weight. The treatment period is 7 days. As a practical dose, 1 gr SEABIT treats 40 kg body weight.
The recommended number of treatment applications; should not exceed 5 treatment applications during the life cycle, provided that it is not more than 3 times within 12 months.