Salcogen Oral Soluble Powder

SALCOGEN Oral Soluble Powder is a yellowish-white, fine-particulate powder and contains in each gram gentamicin sulfate equivalent to 500 mg gentamicin base.

PHARMACOLOGICAL PROPERTIES

Gentamicin is an aminoglycoside group antibiotic with a bactericidal effect against gram positive and gram negative bacteria. Its bactericidal effect occurs by binding to the 30 S ribosomal subunit, preventing the binding of mRNA to these, and causing misreading of the codons in the RNA. The main bacteria susceptible to gentamicin are as follows; E.coli, Enterobacter sp., Campylobacter sp., Klebsiella sp., Yersinia sp., Serratia sp., Haemophilus sp., Pasteurella sp. Pseudomonas aeroginosa strains and Staph. aureus are mostly susceptible. However, other gram positive bacteria, among which are also Streptococcus sp.’, some Pseudomonas sp. and anaerobic bacteria are resistant to gentamicin. When gentamicin is administered orally, it is very poorly absorbed from the gastrointestinal tract. Gentamicin is distributed in the body mainly in the extracellular fluid, accumulating mostly in the kidney, liver and muscular structures. It passes into the placenta from the pleural and peritoneal cavities. It passes into the central nervous system and the cerebrospinal fluid at very low concentrations. Gentamicin is excreted largely in the urine and, in very small amounts, also in the bile and milk.

DOSAGE & ADMINISTRATION

Unless otherwise recommended by the veterinarian;
The pharmacological dose of gentamicin is administered at the following practical doses so as to be 4 mg/kg live weight.
Calf: On the first day of treatment, 1 g SALCOGEN Oral Soluble Powder/100 kg live weight is given, divided into 2 and given 2 times a day; for the following 4-5 days, 0.8 g SALCOGEN Oral Soluble Powder/100 kg live weight is given 1 time a day without dividing the dose.
SALCOGEN Oral Soluble Powder is given orally by adding it to the drinking water. The medicated water must be prepared fresh every day.

GENERAL WARNINGS

‘Consult a veterinarian before use and when an unexpected effect is observed.’
‘Keep out of the reach of children.’ ‘Read the package leaflet before use.’
‘Do not buy or use products whose packaging is damaged.’

STORAGE CONDITIONS AND SHELF LIFE:
When stored at 15-25^oC, in a dry and cool environment at room temperature, in closed packaging, the shelf life is 2 years.

WARNINGS FOR NON-TARGET SPECIES:
It should not be used in small rodents such as rabbits, guinea pigs and hamsters, or in webbed-footed animals such as geese and ducks.

PRESENTATION:
It is offered for sale in 20 g plastic bottles as boxed, and in 250 g, 500 g, 1 kg and 2.5 kg white plastic jars without a box. 

INDICATIONS

SALCOGEN Oral Soluble Powder is used in calves for the treatment of Colibacillosis and Salmonellosis in particular, as well as other gastro-intestinal infections caused by microorganisms susceptible to gentamicin.